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Multiscale Models
Example
Let’s go through an example. We’ll construct a model in which an intracellular cell cycle network (ODE) regulates the division of motile cells which (CPM) release a diffusive cytokine (PDE) which, in turn, controls the cell cycle (ODE).
Models
Published Models
Zebrafish
Guidance by Followers
Morpheus Model ID:
M0006
The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations. Introduction Collective cell migration is an important process during biological development and tissue repair.
A. Boutillon
,
S. Escot
,
A. Elouin
,
D. Jahn
,
S. González-Tirado
,
J. Starruß
,
L. Brusch
,
N. B. David
(Authors)
D. Jahn
(Contributor)
DOI:10.1016/j.devcel.2022.05.001
Models
Published Models
Human
Spatial Effects on Killing Kinetics of Cytotoxic T Lymphocytes
Morpheus Model ID:
M9495
This model also requires the separate file boundary.tiff. Introduction The immune system plays an important role in controlling infections and tumors. Knowledge about the mechanisms through which the immune system accomplishes this can be exploited to develop immunotherapies.
R. J. Beck
,
D. I. Bijker
,
J. B. Beltman
(Authors)
J. B. Beltman
,
D. Jahn
(Contributors)
DOI:10.1371/journal.pcbi.1007972
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