Posts
Events
Download
Models
Overview
Built-in Examples
Contributed Examples
Published Models
Submit Model
Courses
Publications
Support
In-app Docs
FAQ
Wiki
User Forum
Issue Tracker
Twitter
Light
Dark
Automatic
Differential Adhesion
Models
Built-in Examples
Cellular Potts Models
Differential Adhesion: Cell Sorting in Two Dimensions
Morpheus Model ID:
M0021
Introduction This model shows the original cellular Potts model (a.k.a. Glazier-Graner model) of cell sorting based on the Steinberg’s differential adhesion hypothesis. Yellow cells engulf the red cells as a result of differential adhesion.
F. Graner
,
J. A. Glazier
(Authors)
Models
Published Models
Principles
Single Genotype Circuit
Morpheus Model ID:
M2053
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Three Layer Circuit
Morpheus Model ID:
M2052
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Two Layer Circuit
Morpheus Model ID:
M2051
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Cell Culture
Human iPSC Wildtype Colony Growth
Morpheus Model ID:
M7671
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Published Models
Cell Culture
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Morpheus Model ID:
M7673
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Published Models
Cell Culture
Human iPSC CDH1-KD : Wildtype Colony Patterning
Morpheus Model ID:
M7672
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Contributed Examples
CPM
Simplified Cell Sorting
Morpheus Model ID:
M2007
A simplified version of the Morpheus cell sorting example Introduction A simplified version of the Morpheus built-in example of M0021"cell sorting showing the effect of cell-cell and cell-medium contact energies on the tissue configuration.
L. Edelstein-Keshet
(Author)
Y. Xiao
(Contributor)
L. Edelstein-Keshet: Mathematical Models in Cell Biology
Selected Publications
Self-organized multicellular structures from simple cell signaling: a computational model
Recent synthetic biology experiments reveal that signaling modules designed to target cell-cell adhesion enable self-organization of …
N. Mulberry
,
L. Edelstein-Keshet
PDF
Cite
DOI
Model
Cite
×