Multiscale Model

‘How can I specify time scales?’

Autoregulatory multicellular incoherent feedforward loop (mIFFL) that generates the 7-stripe even-skipped (eve) expression pattern in Drosophila melanogaster embryogenesis Introduction This model demonstrates the influence of maternal effect genes and gap genes on the even-skipped (eve) gene.

Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

The topic of the upcoming conference bringing together an interdisciplinary community is ‘From Systems Medicine towards Digital …

Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated …